![]() ĭue to the potential cariogenic role of oral Candida species and the synergistic interaction between oral Candida and cariogenic bacteria S. albicans duo-species biofilm setting, with upregulated expression of genes that are related to microbial metabolism and cariogenicity, such as gtfB, gtfC, and gtfD and (e) capable of enhancing virulence and causing more severe caries when co-infected with S. mutans adhesive interaction that is mediated by extracellular polysaccharides (EPS) formation (d) enhancing the virulence of S. mutans cells in biofilms through a unique C. albicans is (a) acidogenic and aciduric (b) capable of dissolving the major tooth component, hydroxyapatite, at an approximately 20-fold rate higher than S. (c) Laboratory findings have added plausible biological evidence of the cariogenic traits of C. mutans carriage and a more cariogenic oral microbiota among individuals with caries. albicans carriage is also positively correlated with S. (b) Our cross-sectional study reported that the oral C. ![]() Similar findings have been reported among the adult population in our recent study. albicans had 5-time greater odds of experiencing caries than children without this yeast strain. A recent meta-analysis showed that children with oral C. albicans) have often been detected at higher levels in the oral cavity of children with caries, compared to caries-free children, and are positively correlated with caries severity. The following scientific evidence supports its potential cariogenic role: (a) Candida species (especially C. The presence of Candida species in the oral cavity is usually found to be positively correlated with poor oral hygiene and high carbohydrate intake. mutans has shed new light on potential fungus-focused approaches to early prediction and subsequent prevention of dental caries. While Streptococcus mutans and Lactobacillus species have traditionally been considered the prime microbial risk markers and preventive targets for dental caries, recent research on the role of Candida species in caries and its synergistic interaction with S. ĭental caries is a chronic infectious disease defined as the local destruction of dental hard tissues by acidic by-products from bacterial fermentation of dietary carbohydrates. albicans and coexisting oral bacteria occur through physical attachment, extracellular signals, and metabolic cross-feeding. albicans and oral microbes affect the biofilm’s cellular and biochemical composition, which influences clinically relevant outcomes of biofilm-related oral diseases such as pathogenesis, virulence, and drug resistance. albicans and oral bacteria have well-documented symbiotic relationships in oral mucositis, periodontal diseases, implant-related infections, and oral cancer. Other Candida species often detected less frequently in the oral cavity include C. Among the oral Candida species, Candida albicans is the most prevalent fungal species that can cause oral candidiasis. Oral candidiasis is the most common fungal infection, with overgrowing Candida species in the superficial epithelium of the oral mucosa. Clinical relevanceĭue to the potential cariogenic role of oral Candida species, antifungal approaches shed new light on the prevention and management of dental caries from a fungal perspective. Future clinical trials are warranted to comprehensively assess the impact of antifungal treatment on the oral flora other than S. The study results indicate that oral antifungal treatment had an effect on S. Furthermore, salivary cytokine eotaxin and fractalkine were significantly reduced at 3-month follow-up among participants who responded to Nystatin rinse ( p < 0.05). albicans isolates were resistant to Nystatin. mutans was significantly reduced at 3-month follow-up ( p 0.05). Half of participants (10/20) were free of salivary C. Candida albicans isolates underwent Nystatin susceptibility test. Twenty-four salivary cytokines were assessed. ![]() Salivary and plaque Candida species and Streptococcus mutans were assessed at baseline and 1-week and 3-month follow-ups. Demographic-socioeconomic-oral-medical conditions were obtained. Twenty healthy adults with oral candidiasis participated in the single-arm clinical trial and received Nystatin oral rinse for 7 days, 4 applications/day, and 600,000 International Units/application. To examine the effect of Nystatin oral rinse on oral Candida species and Streptococcus mutans carriage.
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